Publications

Publications produced within the BeTheCure consortium. Continoulsy updated.

2015 (Jan 2015 – March 2016)

    1. Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS. Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis. Arthritis Rheumatol. 2015 Jul;67(7):1978-80. doi: 10.1002/art.39123.
    2. Alissafi T, Hatzioannou A, Ioannou M, Sparwasser T, Grün JR, Grützkau A, Verginis P. De novo- induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes. J Immunol. 2015 Jun 15;194(12):5812-24.
    3. Aradi B, Kato M, Filkova M, Karouzakis E, Klein K, Scharl M, Kolling C, Michel BA, Gay RE, Buzas EI, Gay S, Jüngel A. Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol. 2015 Oct;67(10):2624-33
    4. Arbore G, West EE, Robertson AB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, O’Neill LA, Coll RC, Sher A, Leonard WJ, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber K, Kemper C. CD4+ T cell-intrinsic complement-NLRP3 inflammasome activity regulates IFN-gamma production. Science 2016, in press.
    5. Arntz OJ, Pieters BC, Oliveira MC, Broeren MG, Bennink MB, de Vries M, van Lent PL, Koenders MI, van den Berg WB, van der Kraan PM, van de Loo FA. Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models. Mol Nutr Food Res. 2015 Sep;59(9):1701-12.
    6. Bachelerie F, Graham GJ, Locati M, Mantovani A, Murphy PM, Nibbs R, Rot A, Sozzani S, Thelen M. An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15. Br J Pharmacol. 2015 Aug;172(16):3945-9. doi: 10.1111/bph.13182.
    7. Benson RA, MacLeod MK, Hale BG, Patakas A, Garside P, Brewer JM. Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. Elife. 2015 Aug 10;4. doi: 10.7554/eLife.06994.
    8. Benson RA, McInnes IB, Brewer JM, Garside P. Cellular imaging in rheumatic diseases. Nat Rev Rheumatol. 2015 Jun;11(6):357-67. doi: 10.1038
    9. Bossini-Castillo L, de Kovel C, Kallberg H, van ‘t Slot R, Italiaander A, Coenen M, Tak PP, Posthumus MD, Wijmenga C, Huizinga T, van der Helm-van Mil AH, Stoeken-Rijsbergen G, Rodriguez-Rodriguez L, Balsa A, González-Álvaro I, González-Gay MA, Gómez-Vaquero C, Franke B; LifeLines Cohort Study, Vermeulen S, van der Horst-Bruinsma I, Dijkmans BA, Wolbink GJ, Ophoff RA, Maehlen MT, van Riel P, Merriman M, Klareskog L, Lie BA, Merriman T, Crusius JB, Brouwer E, Martin J, de Vries N, Toes R, Padyukov L, Koeleman BP. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Ann Rheum Dis. 2015 Mar;74(3):e15.: annrheumdis-2013-204591. doi: 10.1136/annrheumdis-2013-204591. [Epub ahead of print] PubMed PMID: 24532677.
    10. Brink M, Hansson M, Mathsson-Alm L, Wijayatunga P, Verheul MK, Trouw LA, Holmdahl R, Ronnelid J, Klareskog L, Rantapaa-Dahlqvist S. Rheumatoid factor isotypes in relation to antibodies against citrullinated peptides and carbamylated proteins before the onset of rheumatoid arthritis. Arthritis Res Ther. 2016;18(1):43.
    11. Brink M, Verheul MK, Rönnelid J, Berglin E, Holmdahl R, Toes RE, Klareskog L, Trouw LA, Rantapää-Dahlqvist S (2015). Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage. Arthritis Res Ther. 17:25. doi: 10.1186/s13075-015-0536-2. PMID: 25889922.
    12. Budin-Ljøsne, I., H. Teare, J. Kaye and D. Mascalzoni (2015). “Meta consent: Is it new and is it fit for purpose?” BMJ 350: h2146.
    13. Budin-Ljøsne, Mascalzoni D, Soini S, Machado H, Kaye J, Bentzen HB, Rial-Sebbag E, D’Abramo F, Witt M, Schamps G, Katić V,Krajnovic D, Harris JR., Feedback of Individual Genetic Results to Research Participants: Is it Feasible in Europe? Biopreserv Biobank. 2016 Apr 15.
    14. Chemin K, Pollastro S, Albrecht I, Holmdahl R, de Vries N, Malmström V (2016). RA-relevant T cell responses to type II collagen can be influenced by post-translational modifications. Arthritis Rheumatol. doi:10.1002/art.39660. [Epub ahead of print] PMID: 26945919.
    15. Chemin K, Pollastro S, James E, Ge C, Albrecht I, Herrath J, Gerstner C, Tandre K, Rizzi T, Rönnblom L, Catrina A, Holmdahl R, Klareskog L, de Vries N, Malmström V (2015). A novel HLA-DRB1*10:01 restricted T cell epitope from citrullinated type II collagen relevant for Rheumatoid Arthritis. Arthritis Rheumatol. doi: 10.1002/art.39553. [Epub ahead of print] PMID: 26713667.
    16. Chemine K, Pollastro S, James E, Ge C, Albrecht I, Herrath J, Gerstner C, Padyukov L, Catrina AI, Tandre K, Rönnblom L, Holmdahl R, Klareskog L, de Vries N and Malmström V. A novel HLA-DRB1*10:01 restricted T cell epitope from citrullinated type II collagen relevant for Rheumatoid Arthritis. Arthritis Rheumatol 2015; ePub Dec 29. doi: 10.1002/art.39553.
    17. Choi IY, Gerlag DM, Herenius MJ, Thurlings RM, Wijbrandts CA, Foell D, Vogl T, Roth J, Tak PP, Holzinger D. MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Ann Rheum Dis. 2015 Mar;74(3):499-505. doi: 10.1136/annrheumdis-2013-203923.
    18. Danks L, Komatsu N, Guerrini MM, Sawa S, Armaka M, Kollias G, Nakashima T, Takayanagi H. RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation. Ann Rheum Dis. 2015 May 29. pii:annrheumdis-2014-207137. doi: 10.1136/annrheumdis-2014-207137. [Epub ahead of print] PubMed PMID: 26025971.
    19. Doorenspleet ME, Hubers LM, Culver EL, Maillette de Buy Wenniger LJ, Klarenbeek PL, Chapman RW, Baas F, van de Graaf SFJ, Verheij J, van Gulik TM, Barnes E, Beuers U, and N. de Vries. Immunoglobulin G4+ B-Cell Receptor Clones Distinguish Immunoglobulin G4-Related Disease From Primary Sclerosing Cholangitis and Biliary/ Pancreatic Malignancies. Hepatology 2016 in press.
    20. Duroux-Richard I, Cuenca J, Ponsolles C, Piñeiro AB, Gonzalez F, Roubert C, Areny R, Chea R, Pefaur J, Pers YM, Figueroa FE, Jorgensen C, Khoury M, Apparailly F. MicroRNA Profiling of B Cell Subsets from Systemic Lupus Erythematosus Patients Reveals Promising Novel Biomarkers. Int J Mol Sci. 2015 Jul 27;16(8):16953-65.
    21. Ederveen THA, Rogier R, Boekhorst J, Wopereis H, Garssen J, Walgreen B, Helsen MM, van den Bersselaar L, van Lent PL, van de Loo FA, van der Kraan PM, van Hijum SAFT, van den Berg WB, Koenders MI, Abdollahi-Roodsaz S. Toll-like receptor 4-induced interleukin-1 defines the intestinal microbiome and mucosal immune response in autoimmune-prone mice. (submitted)
    22. Engler A, Tange C, Frank-Bertoncelj M, Gay RE, Gay S and Ospelt C. Regulation and function of SIRT1 in rheumatoid arthritis synovial fibroblasts. Journal of molecular medicine (2015)
    23. F Ponchel, AN Burska, EA Hensor R Raja, M Campbell, P Emery, PG Conaghan. Changes in peripheral blood immune cell composition in osteoarthritis. Osteoarthritis and Cartilage, 2015. 23 1870 -1878 (doi:10.1016/j.joca.2015.06.018)
    24. F Ponchel, AN Burska, SR Harrison. Immunological Biomarkers for Patient Stratification. Translational Immunology: Mechanisms and Pharmacologic Approaches. Oxford Press.
    25. Fernandes-Cerqueira C, Ossipova E, Gunasekera S, Hansson M, Mathsson L, Catrina AI, Sommarin Y, Klareskog L, Lundberg K, Ronnelid J, Goransson U, Jakobsson PJ. Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens. Arthritis Res Ther. 2015;17:155.
    26. Frisell T, Saevarsdottir S, Askling J. Does a family history of RA influence the clinical presentation and treatment response in RA? Ann Rheum Dis. 2016 Jun;75(6):1120-5. doi: 10.1136/annrheumdis-2015-207670. Epub 2015 Jun 19.
    27. G.N. Goulielmos, M.I. Zervou, A.N. Burska & F. Ponchel. Questions posed by personalized medicine achievements and promise. J of Clinical Research & Bioethics, 2016, doi:10.4172/2155-9627.1000257
    28. G.N. Goulielmos, M.I. Zervou, E. Myrthianou, A.N. Burska, TB. Niewold, F. Ponchel. Genetic data: the new challenge of personalized medicine, insights for Rheumatoid Arthritis patients. Gene, 2016;583(2):90-101. doi: 10.1016/j.gene.
    29. Gainotti, S., C. Turner, S. Woods, A. Kole, P. McCormack, H. Lochmüller, O. Riess, V. Straub , M. Posada, D. Taruscio and D. Mascalzoni. “Improving the informed consent process in international collaborative rare disease research” European Journal of Human Genetics, 2016
    30. Gerlag DM, Norris JM, Tak PP. Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment. Rheumatology (Oxford). 2016 Apr;55(4):607-14. doi: 10.1093/rheumatology/kev347.
    31. Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Sci Adv. 2016 Feb 5;2(2):e1501257. doi: 10.1126/sciadv.1501257. eCollection 2016 Feb.PMID: 26989780
    32. Goulielmos GN, Zervou MI, Myrthianou E, Burska A, Niewold TB, Ponchel F. Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients. Gene. 2016 Jun 1;583(2):90-101. doi: 10.1016/j.gene.2016.02.004. Epub 2016 Feb 8.
    33. Guerard S, Boieri M, Hultqvist M, Holmdahl R, Wing K. The SKG mutation in ZAP-70 also confers arthritis susceptibility in C57 black mouse strains. Scand J Immunol. 2016 Apr 4. doi: 10.1111/sji.12438. PMID: 27040161
    34. Haag S, Tuncel J, Thordardottir S, Mason DE, Yau AC, Dobritzsch D, Bäcklund J, Peters EC, Holmdahl R (2015). Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis. J Immunol. 194(6):2539-50. doi: 10.4049/jimmunol.1402238. PMID: 25672758.
    35. Haftmann C, Riedel R, Porstner M, Wittmann J, Chang HD, Radbruch A, Mashreghi MF. Direct uptake of Antagomirs and efficient knockdown of miRNA in primary B and T lymphocytes. J Immunol Methods. 2015 Nov;426:128-33. doi: 10.1016/j.jim.2015.07.006. Epub 2015 Jul 15.
    36. Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF. miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim. Eur J Immunol. 2015 Apr;45(4):1192-205. doi: 10.1002/eji.201444633. Epub 2015 Jan 22.
    37. Harre U, Lang SC, Pfeifle R, Rombouts Y, Frühbeißer S, Amara K, Bang H, Lux A, Koeleman CA, Baum W, Dietel K, Gröhn F, Malmström V, Klareskog L, Krönke G, Kocijan R, Nimmerjahn F, Toes RE, Herrmann M, Scherer HU, Schett G. Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nat Commun 2015 31;6:6651.
    38. Häupl T, Zimmermann M, Kalus U, Yürek S, Koscielny J, Hoppe B. Angiotensin converting enzyme intron 16 insertion/deletion genotype is associated with plasma C-reactive protein concentration in uteroplacental dysfunction. J Renin Angiotensin Aldosterone Syst. 2015 Jun;16(2):422-7. doi: 10.1177/1470320314539181.
    39. Hensvold AH, Frisell T, Magnusson PK, Holmdahl R, Askling J, Catrina AI. How well do ACPA discriminate and predict RA in the general population: a study based on 12 590 population-representative Swedish twins. Ann Rheum Dis. 2016 Apr 28. pii: annrheumdis-2015-208980. doi: 10.1136/annrheumdis-2015-208980. [Epub ahead of print]
    40. Hensvold AH, Joshua V, Li W, Larkin M, Qureshi F, Israelsson L, Padyukov L, Lundberg K, Defranoux N, Saevarsdottir S, Catrina AI. Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate. Arthritis Res Ther. 2015 Sep 4;17:239. doi: 10.1186/s13075-015-0760-9.
    41. Holmdahl R, Sareila O, Olsson LM, Bäckdahl L, Wing K (2016). Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation. Immunol Rev. 269(1):228-47. doi: 10.1111/imr.12378. Review. PMID: 26683156.
    42. Holmdahl, R. (2015), “Animal models for rheumatoid arthritis”, in Hansen, A.K. (ed.), Animal Models in Biomedical Research, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London. (For online version: https://hstalks.com/t/3076/animal-models-for-rheumatoid-arthritis/?biosci)
    43. Jansen DT, el Bannoudi H, Arens R, Habets KL, Hameetman M, Huizinga TW, Stoop JN, Toes RE. Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model. Arthritis Res Ther. 2015 Aug 20;17:220. doi: 10.1186/s13075-015-0731-1
    44. Karpus ON, Kiener HP, Niederreiter B, Yilmaz-Elis AS, van der Kaa J, Ramaglia V, Arens R, Smolen JS, Botto M, Tak PP, Verbeek J, Hamann J. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Arthritis Research & Therapy. 2015 January in press
    45. Kerkman PF, Fabre E, van der Voort EI, Zaldumbide A, Rombouts Y, Rispens T, Wolbink G, Hoeben RC, Spits H, Baeten DL, Huizinga TW, Toes RE, Scherer HU. Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis. Ann Rheum Dis. 2015 Jun 1. pii: annrheumdis-2014-207182. doi: 10.1136/annrheumdis-2014-207182.
    46. Khmaladze Ia, Saxena A, Nandakumar KS, Holmdahl R (2015). B-cell epitope spreading and inflammation in a mouse model of arthritis is associated with a deficiency in reactive oxygen species production. Eur J Immunol. 45(8):2243-51. doi: 10.1002/eji.201545518. Epub 2015 Jun 3. PMID: 25989352.
    47. Klein K, Kabala PA, Grabiec AM, Gay RE, Kolling C, Lin LL, Gay S, Tak PP, Prinjha RK, Ospelt C and Reedquist KA (2016) The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts. Ann Rheum Dis 75(2): 422-429
    48. Klein K., and Gay S. Epigenetics in rheumatoid arthritis. 2015. Curr Opin Rheumatol 27, 76 82
    49. Klocke K, Sakaguchi S, Holmdahl R and Wing K (2016). Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood. Proc Natl Acad Sci U S A. pii: 201603892. [Epub ahead of print]
    50. Koenders MI, van den Berg WB. Novel therapeutic targets in rheumatoid arthritis. Trends Pharmacol Sci. 2015 Apr;36(4):189-95.
    51. Kokkonen H, Brink M, Hansson M, Lassen E, Mathsson-Alm L, Holmdahl R, Ronnelid J, Klareskog L, Rantapaa-Dahlqvist S. Associations of antibodies against citrullinated peptides with human leukocyte antigen-shared epitope and smoking prior to the development of rheumatoid arthritis. Arthritis Res Ther. 2015;17:125.
    52. Krishnamurthy A, Joshua V, Hensvold A, Sun M, Ytterberg AJ, Engström M, Catrina S-B, Amara K, Malmström V, Klareskog L, Wähämaa H and Catrina AI. Identification of a novel chemokine-dependent molecular mechanism by which Rheumatoid Arthritis-associated autoantibodies mediate bone destruction. 2016 Ann Rheum Dis 75:721-9.
    53. L Hunt, EM Hensor, J Nam, A Burska, R Parmar, P Emery, F Ponchel. T-cell subsets: An immunological biomarker to predict progression to clinical arthritis in ACPA positive individuals. Annals Rheum Dis 2015, annrheumdis-2015-207991.
    54. Lindgren C, Andersson IE, Berg L, Dobritzsch D, Ge C, Haag S, Uciechowska U, Holmdahl R, Kihlberg J, Linusson A (2015). Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes. Org Biomol Chem. 13(22):6203-16. doi: 10.1039/c5ob00395d. PMID: 25960177.
    55. López-Posadas R, Becker C, Günther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Ekici AB, Wirtz S, Thonn V, Watson AJ, Brakebusch C, Bergö M, Neurath MF, Atreya I. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J Clin Invest. 2016 Feb 1;126(2):611-26
    56. Luz-Crawford P, Tejedor G, Mausset-Bonnefont AL, Beaulieu E, Morand EF, Jorgensen C, Noël D, Djouad F. Glucocorticoid-induced leucine zipper governs the therapeutic potential of mesenchymal stem cells by inducing a switch from pathogenic to regulatory Th17 cells in a mouse model of collagen-induced arthritis. Arthritis Rheumatol. 2015 Jun;67(6):1514-24.
    57. Maijer KI, Gerlag DM, Tak PP. Prevalence of Anti-Citrullinated Protein Antibodies and IgM Rheumatoid Factor in First-Degree Relatives of Dutch Rheumatoid Arthritis Patients. Arthritis Rheumatol. 2015 Dec;67(12):3324-6. doi: 10.1002/art.39412.
    58. Maijer KI, Gudmann NS, Karsdal MA, Gerlag DM, Tak PP, Bay-Jensen AC. Neo-Epitopes-Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis. PLoS One. 2016 Mar 28;11(3):e0149329. doi: 10.1371
    59. Maijer KI, Li W, Sasso EH, Gerlag DM, Defranoux NA, Tak PP. Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis? Ann Rheum Dis. 2015 Nov;74(11):2097-9. doi: 10.1136/annrheumdis-2015-207911.
    60. Maijer KI, Neumann E, Müller-Ladner U, Drop DA, Ramwadhdoebe TH, Choi IY, Gerlag DM, de Hair MJ, Tak PP. Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals. PLoS One. 2015 Dec 15;10(12):e0144932. doi: 10.1371
    61. Maijer KI, van der Leij C, de Hair MJ, Tas SW, Maas M, Gerlag DM, Tak PP, Lavini C. Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Pharmacokinetic Modeling: Initial Experience in Patients With Early Arthritis. Arthritis Rheumatol. 2016 Mar;68(3):587-96. doi: 10.1002/art.39469.
    62. Mascalzoni, D., E. S. Dove, Y. Rubinstein, H. J. Dawkins, A. Kole, P. McCormack, S. Woods, O. Riess, F. Schaefer, H. Lochmuller, B. M. Knoppers and M. Hansson (2015). “International Charter of principles for sharing bio-specimens and data.” European Journal of Human Genetics 23(6): 721-728.
    63. Matz M, Fabritius K, Lorkowski C, Dürr M, Gaedeke J, Durek P, Grün JR, Goestemeyer A, Bachmann F, Wu K, Rudolph B, Schmidt D, Weber U, Haftmann C, Unterwalder N, Lachmann N, Radbruch A, Neumayer HH, Mashreghi MF, Budde K. Identification of T Cell-Mediated Vascular Rejection After Kidney Transplantation by the Combined Measurement of 5 Specific MicroRNAs in Blood. Transplantation. 2016 Apr;100(4):898-907. doi: 10.1097/TP.0000000000000873.
    64. Mebarek N, Vicente R, Aubert-Pouëssel A, Quentin J, Mausset-Bonnefont AL, Devoisselle JM, Jorgensen C, Bégu S, Louis-Plence P. Versatile polyion complex micelles for peptide and siRNA vectorization to engineer tolerogenic dendritic cells. Eur J Pharm Biopharm. 2015 May;92:216-27.
    65. Müller M, Herrath J and Malmström V. Helios+ and Helios- FOXP3+ T cells in the rheumatic joint represent distinct T cell subsets. Clin Exp Immunol 2015;182:90-100.
    66. Nair SC, Welsing PM, Choi IY, Roth J, Holzinger D, Bijlsma JW, van Laar JM, Gerlag DM, Lafeber FP, Tak PP. A Personalized Approach to Biological Therapy Using Prediction of Clinical Response Based on MRP8/14 Serum Complex Levels in Rheumatoid Arthritis Patients. PLoS One. 2016 Mar 30;11(3):e0152362. doi: 10.1371
    67. Oliveira MC, Arntz OJ, Blaney Davidson EN, van Lent PL, Koenders MI, van der Kraan PM, van den Berg WB, Ferreira AV, van de Loo FA. Milk extracellular vesicles accelerate osteoblastogenesis but impair bone matrix formation. J Nutr Biochem. 2016 Apr;30:74-84.
    68. Ospelt C and Gay S (2015) Response to: ‘Cadmium the missing link between smoking and increased rheumatoid disease activity?’ by Cates and Hutchinson. Ann Rheum Dis 74(1): e2
    69. Pallai A, Kiss B, Vereb G, Armaka M, Kollias G, Szekanecz Z, Szondy Z. Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications. J Immunol. 2016 Feb 1;196(3):1146-57. doi:10.4049/jimmunol.1501573. Epub 2016 Jan 4. PubMed PMID: 26729808.
    70. Patakas A, Ji RR, Weir W, Connolly SE, Benson RA, Nadler SG, Brewer JM, McInnes IB, Garside P. Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen-Presenting Cells. Arthritis Rheumatol. 2016 Mar;68(3):627-38. doi: 10.1002
    71. Pauline McCormack, Anna Kole, Sabina Gainotti, Deborah Mascalzoni, Caron Molster, Hanns Lochmuller, Simon Woods “You should at least ask” The expectations, hopes and fears of rare disease patients on large scale data and biomaterial sharing for genomics research. EJHG 2016
    72. Pieters BC, Arntz OJ, Bennink MB, Broeren MG, van Caam AP, Koenders MI, van Lent PL, van den Berg WB, de Vries M, van der Kraan PM, van de Loo FA. Commercial cow milk contains physically stable extracellular vesicles expressing immunoregulatory TGF-β. PLoS One. 2015 Mar 30;10(3):e0121123.
    73. Pikwer M, Orellana C, Källberg H, Pikwer A, Turesson C, Klareskog L, Alfredsson L, Saevarsdottir S, Bengtsson C. Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material. Arthritis Res Ther. 2015 Dec 12;17:358. doi: 10.1186/s13075-015-0869-x.
    74. Platt AM, Benson RA, McQueenie R, Butcher JP, Braddock M, Brewer JM, McInnes IB, Garside P. The active metabolite of spleen tyrosine kinase inhibitor fostamatinib abrogates the CD4⁺ T cell-priming capacity of dendritic cells. Rheumatology (Oxford). 2015 Jan;54(1):169-77. doi: 10.1093
    75. Porstner M, Winkelmann R, Daum P, Schmid J, Pracht K, Côrte-Real J, Schreiber S, Haftmann C, Brandl A, Mashreghi MF, Gelse K, Hauke M, Wirries I, Zwick M, Roth E, Radbruch A, Wittmann J, Jäck HM. miR-148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2. Eur J Immunol. 2015 Apr;45(4):1206-15. doi: 10.1002/eji.201444637. Epub 2015 Mar 12.
    76. R. Vicente, N. Mebarek, A. Aubert-Pouëssel, J. Quentin, A-L. Mausset-Bonnefont, J-M. Devoisselle, C. Jorgensen, S. Bégu and P. Louis-Plence. Versatile polyion complex micelles for peptide and siRNA vectorization to engineer tolerogenic dendritic cells. Eur J Pharm Biopharm. 2015 May;92:216-27.
    77. R. Vicente, J Quentin, A-L Mausset-Bonnefont, P Chuchana, D Martire, M Cren, C Jorgensen and P. Louis-Plence. Non-classical CD4+CD49b+ regulatory T cells as a better alternative to conventional CD4+CD25+ T cells to dampen arthritis severity. J Immunol. 2016 Jan 1;196(1):298-309.
    78. Raposo B, Vaartjes D, Ahlqvist E, Nandakumar KS, Holmdahl R (2015). System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis. Immunology.146(4):607-17. doi: 10.1111/imm.12531. Epub 2015 Oct 5. PMID: 26346312.
    79. Rivellese F, Suurmond J, Habets K, Dorjée AL, Ramamoorthi N, Townsend MJ, de Paulis A, Marone G, Huizinga TW, Pitzalis C, Toes RE. Ability of Interleukin-33- and Immune Complex-Triggered Activation of Human Mast Cells to Down-Regulate Monocyte-Mediated Immune Responses. Arthritis Rheumatol. 2015 Sep;67(9):2343-53. doi: 10.1002/art.39192
    80. Roberts JM, Mascalzoni D, Ness RB, Poston L; Global Pregnancy Collaboration. “Collaboration to Understand Complex Diseases: Preeclampsia and Adverse Pregnancy Outcomes.” Hypertension. 2016 Apr;67(4):681-7. 2016
    81. Roeleveld DM, Koenders MI. The role of the Th17 cytokines IL-17 and IL-22 in Rheumatoid Arthritis pathogenesis and developments in cytokine immunotherapy. Cytokine. 2015 Jul;74(1):101-7.
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    83. Sabine Baumgart, Anette Peddinghaus, Ursula Schulte-Wrede, and Andreas Grützkau. OMIP-MC – 001: Comprehensive immunophenotyping of human peripheral leukocyte subsets by mass cytometry for monitoring immunomodulatory clinical studies. (accepted for publication in CYTOMETRY Part A)
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    87. Sörensen T, Baumgart S, Durek P, Grützkau A, Häupl T. ImmunoClust–An automated analysis pipeline for the identification of immunophenotypic signatures in high-dimensional cytometric datasets. Cytometry A. 2015 Jul;87(7):603-15. doi: 10.1002/cyto.a.22626.
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Sozzani S, Del Prete A, Bonecchi R, Locati M. Chemokines as effector and target molecules in vascular biology. Cardiovasc Res. 2015 Aug 1;107(3):364-72. doi: 10.1093/cvr/cvv15
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    93. Tacconi C, Correale C, Gandelli A, Spinelli A, Dejana E, D’Alessio S, Danese S. Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion Gastroenterology. 2015 Jun;148(7):1438-51
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    95. van Heemst J, Trouw LA, Nogueira L, van Steenbergen HW, van der Helm-van Mil AH, Allaart CF, Serre G, Holmdahl R, Huizinga TW, Toes RE, van der Woude D (2015). An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting. Arthritis Res Ther. 17:276. doi:10.1186/s13075-015-0786-z. PMID: 26437716.
    96. van Nieuwenhuijze AE, van de Loo FA, Walgreen B, Bennink M, Helsen M, van den Bersselaar L, Wicks IP, van den Berg WB, Koenders MI. Complementary action of granulocyte macrophage colony-stimulating factor and interleukin-17A induces interleukin-23, receptor activator of nuclear factor-κB ligand, and matrix metalloproteinases and drives bone and cartilage pathology in experimental arthritis: rationale for combination therapy in rheumatoid arthritis. Arthritis Res Ther. 2015 Jun 17;17:163.
    97. Van Nieuwenhuijze AEM, Roeleveld DM, Walgreen B, Bennink M, Helsen MM, van den Bersselaar L, Wicks I, van den Berg WB, Koenders MI. Synergism between GM-CSF and IL-17 causes joint damage via the production of IL-23, Receptor Activator of NF-κB Ligand and matrix metalloproteinases. (submitted)
    98. Vermeij EA, Koenders MI, Bennink MB, Crowe LA, Maurizi L, Vallée JP, Hofmann H, van den Berg WB, van Lent PL, van de Loo FA. The in-vivo use of superparamagnetic iron oxide nanoparticles to detect inflammation elicits a cytokine response but does not aggravate experimental arthritis. PLoS One. 2015 May 8;10(5):e0126687.
    99. Vicente R, Mebarek N, Aubert-Pouëssel A, Quentin J, Mausset-Bonnefont A-L, Devoisselle J-M, Jorgensen C, Bégu S, Louis-Plence P. Versatile polyion complex micelles for peptide and siRNA vectorization to engineer tolerogenic dendritic cells. Eur J Pharm Biopharm. 2015 May;92:216-27.
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2014

 

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  2. Ball EM, Tan AL, Fukuba E, McGonagle D, Grey A, Steiner G, Bell AL, Rooney MR. A study of erosive phenotypes in lupus arthritis using magnetic resonance imaging and anti-citrullinated protein antibody, anti-RA33 and RF autoantibody status. Rheumatology (Oxford). 2014;53(10):1835-43.
  3. Benson RA, Brewer JM, Platt AM. Mechanisms of autoimmunity in human diseases: a critical review of current dogma. Curr Opin Rheumatol. 2014 Mar;26(2):197-203.
  4. Bonelli M, Göschl L, Blüml S, Karonitsch T, Steiner CW, Steiner G, Smolen JS, Scheinecker C. CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis? Arthritis Res Ther. 2014;16(2):R104
  5. Bossini-Castillo L, de Kovel C, Kallberg H, van ‘t Slot R, Italiaander A, Coenen M, Tak PP, Posthumus MD, Wijmenga C, Huizinga T, van der Helm-van Mil AH et al. A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Ann Rheum Dis. 2014 Feb 14. pii: annrheumdis-2013-204591
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  12. Churchman SM, JJ El-Jawhari, AN Burska, R Parmar, V Goëb, PG Conaghan, P Emery, F Ponchel. Modulation of peripheral T-cell function by interleukin-7 in Rheumatoid Arthritis. Arthritis research & therapy 16 (6), 511
  13. D’Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet L, Fiocchi C, Danese S. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease. J Clin Invest. 2014 Sep 2;124(9):3863-78.
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  30. Haag S, Jonatan Tuncel J, Thordardottir S, Mason DE, Yau ACY, Dobritzsch D, Bäcklund J, Peters EC, Holmdahl R: Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis. J Immunol 2015 (in press).
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  33. Herrath J, Chemin K, Albrecht I, Catrina AI, Malmström V. Surface expression of CD39 identifies an enriched Treg-cell subset in the rheumatic joint, which does not suppress IL-17A secretion. Eur J Immunol. 2014 Oct;44(10):2979-89.
  34. Holmdahl R, Malmström V, Burkhardt H. Autoimmune priming tissue attack and chronic inflammation – The three stages of rheumatoid arthritis.Eur J Immunol.2014 Jun;44(6):1593-9
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  48. Koenders MI, van den Berg WB. Novel therapeutic targets in arthritis. Trends Pharmacol Sci (accepted for publication)
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  64. Ponchel F, Burska A, Myrthianou E, Goulielmos G. Advances in Medicine and Biology. Volume 77, in the book “IL-7 in Rheumatoid Arthritis: Pathogenesis, Biomarker and Rationale for Anti-IL-7 Therapy” free of charge to anyone withInternet access here
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  69. Raaschou P, Frisell T, Askling J; for the ARTIS Study Group. TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study. Ann Rheum Dis. 2014 Aug 8. pii: annrheumdis-2014-205745. doi: 10.1136/annrheumdis-2014-205745
  70. Raposo B, Dobritzsch D, Ge C, Ekman D, Xu B, Lindh I, Förster M, Uysal H, Nandakumar KS, Schneider G, Holmdahl R: Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms. J Exp Med. 2014 Mar 10;211(3):405–11
  71. Rivellese F, Suurmond J, de Paulis A, Marone G, Huizinga TW, Toes RE. IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation. Eur J Immunol. 2014 Oct;44(10):3045-55.
  72. Roeleveld DM, Koenders MI. The role of the Th17 cytokines IL-17 and IL-22 in Rheumatoid Arthritis pathogenesis and developments in cytokine immunotherapy. 2014 Cytokine Nov 20. pii: S1043-4666(14)00550-X
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  74. Roulis M, Nikolaou C, Kotsaki E, Kaffe E, Karagianni N, Koliaraki V, Salpea K, Ragoussis J, Aidinis V, Martini E, Becker C, Herschman HR, Vetrano S, Danese S, Kollias G. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4658-67.
  75. Shi J, van de Stadt LA, Levarht EW, Huizinga TW, Hamann D, van Schaardenburg D, Toes RE, Trouw LA. Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis. Ann Rheum Dis. 2014 Apr;73(4):780-3.
  76. Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, Toes RE, Trouw LA. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014 Mar;13(3):225-30.
  77. Sipilä K, Haag S, Denessiouk K, Käpylä J, Peters EC, Denesyuk A, Hansen U, Konttinen Y, Johnson MS, Holmdahl R, Heino J. Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. FASEB J. 2014 Aug;28(8):3758-68. doi: 10.1096/fj.13-247767. Epub 2014 May 13.
  78. Stoop JN, Fischer A, Hayer S, Hegen M, Huizinga TW, Steiner G, Trouw LA, Toes RE: Anti-carbamylated protein antibodies can be detected in animal models of arthritis that require active involvement of the adaptive immune system. Annals of the Rheumatic Diseases 2015 (In press)
  79. Stoop JN, Liu BS, Shi J, Jansen DT, Hegen M, Huizinga TW, Trouw LA, Toes RE: Antibodies specific for carbamylated proteins precede the onset of clinical symptoms in mice with collagen induced arthritis. PlosOne, 2014 Jul 15;9(7):e102163
  80. Suurmond J, Rivellese F, Dorjée AL, Bakker AM, Rombouts YJ, Rispens T, Wolbink G, Zaldumbide A, Hoeben RC, Huizinga TW, Toes RE. Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies. Ann Rheum Dis. 2014 May 12.
  81. Suurmond J, Stoop JN, Rivellese F, Bakker AM, Huizinga TW, Toes RE. Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells. Eur J Immunol. 2014 Feb;44(2):386-96.
  82. Suwannalai P, Britsemmer K, Knevel R, Scherer HU, Levarht EW, van der Helm-van Mil AH, van Schaardenburg D, Huizinga TW, Toes RE, Trouw LA. Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis. Ann Rheum Dis. 2014 Jan;73(1):270-6.
  83. Sörensen T, Baumgart S, Durek P, Grützkau A, Häupl T. ImmunoClust – an automated analysis pipeline for the identification of immunophenotypic signatures in high dimensional cytometric datasets. CYTOMETRY Part A 2014 (manuscript accepted for publication)
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  85. Tschismarov R, Firner S, Gil-Cruz C, Göschl L, Boucheron N, Steiner G, Matthias P, Seiser C, Ludewig B, Ellmeier W. HDAC1 controls CD8+ T cell homeostasis and the antiviral CD8+ T cell response. Plos One 2014;9(10):e110576.
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2013

1. Abdollahi-Roodsaz S, Koenders MI, Walgreen B, Bolscher J, Helsen MM, van den Bersselaar LA, van Lent PL, van de Loo FA, van den Berg WB. Toll-like receptor 2 controls acute immune complex-driven arthritis in mice by regulating the inhibitory Fcγ receptor IIB. Arthritis Rheum. 2013; 65(10):2583-93

2. Akhilesh Kumar Shakya, Rikard Holmdahl, Kutty Selva Nandakumar and Ashok Kumar Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants. Vaccine in press 2013

3. Amara K, Steen J, Murray F, Morbach H, Fernandez-Rodriguez BM, Joshua V, Engström M, Snir O, Israelsson L, Catrina AI, Wardemann H, Corti D, Meffre E, Klareskog L, Malmström V. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J Exp Med. 2013 Mar 11;210(3):445-55.

4. Ammari M, Jorgensen C, Apparailly F. Impact of microRNAs on the understanding and treatment of rheumatoid arthritis. Current opinion in rheumatology 2013, 25(2): 225-233

5. Apparailly, F.& C. Jorgensen. siRNA-based therapeutic approaches for rheumatic diseases. Nature Reviews Rheumatology 2013, 9(1): 56-62.

6. Becker C., A.J. Watson, M.F.Neurath. The Intricate Role of Caspases in the Pathogenesis of Inflammatory Bowel Disease. Gastroenterology. 2013. 144(2):283-93.

7. Biliavska I, Stamm TA, Martinez-Avila J, Huizinga TWJ, Landewe RBM, Steiner G, Aletaha D, Smolen JS, Machold KP. Application of the 2010 ACR/EULAR classification criteria in patients with very early inflammatory arthritis: analysis of sensitivity, specificity and predictive values in the SAVE study cohort. Ann Rheum Dis 2013; 72:1335–41.

8. Blüml S, Friedrich M, Lohmeyer T, Sahin E, Saferding V, Brunner J, Puchner A, Mandl P, Niederreiter B, Smolen JS, Schabbauer G, Redlich K. Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells. Ann Rheum Dis 2013 (doi: 10.1136/annrheumdis-2013-203486).

9. Bonelli M, Ferner E, Göschl L, Blüml S, Hladik A, Karonitsch T, Kiener H, Byrne R, Niederreiter B, Steiner C, Rath E, Bergmann M, Smolen J, Scheinecker C. Abatacept (CTLA-4lg) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis (RA). Arthritis Rheum 2013;65(3):599-607.

10. Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, Stenlund H, Rönnelid J, Klareskog L, and Rantapää Dahlqvist S. Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum 2013; 65(4):899-910

11. Camus, M., Esses, S., Pariente, B., Le Bourhis, L., Douay, C., Chardiny, V., Mocan, I., Benlagha, K., Clave, E., Toubert, A., Mayer, L., Allez, M. Oligoclonal expansions of mucosal T cells in Crohn’s disease predominate in NKG2D-expressing CD4 T cells. Mucosal Immunol. 2013. doi: 10.1038/mi.2013.51.

12. Chen XX, Baum W, Dwyer D, Stock M, Schwabe K, Ke HZ, Stolina M, Schett G, Bozec A. Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis. Ann Rheum Dis. 2013;72(10):1732-6

13. Choi Ivy Y, Danielle M Gerlag, Marieke J Herenius, Rogier M Thurlings, Carla A Wijbrandts, Dirk Foell, Thomas Vogl, Johannes Roth, Paul P Tak, Dirk Holzinger. MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis. Ann Rheum Dis doi:10.1136/annrheumdis-2013-203923

14. Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T, Mirkov MU, Canhao H, Ikari K, Terao C, Okada Y, Wedrén S, Askling J, Yamanaka H, Momohara S, Taniguchi A, Ohmura K, Matsuda F, Mimori T, Gupta N, Kuchroo M, Morgan AW, Isaacs JD, Wilson AG, Hyrich KL, Herenius M, Doorenspleet ME, Tak PP, Crusius JB, van der Horst-Bruinsma IE, Wolbink GJ, van Riel PL, van de Laar M, Guchelaar HJ, Shadick NA, Allaart CF, Huizinga TW, Toes RE, Kimberly RP, Bridges SL Jr, Criswell LA, Moreland LW, Fonseca JE, de Vries N, Stranger BE, De Jager PL, Raychaudhuri S, Weinblatt ME, Gregersen PK, Mariette X, Barton A, Padyukov L, Coenen MJ, Karlson EW, Plenge RM. Genome-wide association study and gene expression analysis identifies CD84 as a predictor of to etanercept therapy in rheumatoid arthritis. PLoS Genet. 2013 Mar;9(3):e1003394

15. Damgaard D, Palarasah Y, Skjødt K, Catrina AI, Hensen SM, Pruijn GJ, Nielsen CH. Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay. J Immunol Methods. 2013 Dec 31. pii: S0022-1759(13)00372-4.

16. de Hair JH, Maria, Robert B M Landewé, Marleen G H van de Sande, Dirkjan van Schaardenburg, Lisa G M van Baarsen, Danielle M Gerlag, Paul P Tak. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis 2013;72:1654-1658

17. de Hair MJ, van de Sande MG, Ramwadhdoebe TH, Hansson M, Landewé R, van der Leij C, Maas M, Serre G, van Schaardenburg D, Klareskog L, Gerlag DM, van Baarsen LG, Tak PP. Features of the synovium of individuals at risk of developing rheumatoid arthritis: Implications for understanding preclinical rheumatoid arthritis. Arthritis Rheum. 2013 Nov 18. doi: 10.1002/art.38273.

18. Doorenspleet ME, Klarenbeek PL, de Hair MJ, van Schaik BD, Esveldt RE, van Kampen AH, Gerlag DM, Musters A, Baas F, Tak PP, de Vries N. Rheumatoid arthritis synovial tissue harbours dominant B-cell and plasma-cell clones associated with autoreactivity. Ann Rheum Dis. 2013 Apr 20. [Epub ahead of print]

19. Filková M, Aradi B, Senolt L, Ospelt C, Vettori S, Mann H, Filer A, Raza K, Buckley CD, Snow M, Vencovsky J, Pavelka K, Michel BA, Gay RE, Gay S, Jüngel A. Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. Ann Rheum Dis, 2013 [Epub ahead of print] IF: 8.272

20. Frisell T, Holmqvist M, Källberg H, Klareskog L, Alfredsson L, Askling J. Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age. Arthritis Rheum. 2013 Nov;65(11):2773-82.

21. Gay S, Wilson AG. The emerging role of epigenetics in rheumatic diseases. Rheumatology (Oxford). 2013 Sep 11. [Epub ahead of print]

22. García-Bermúdez M, López-Mejías R, Genre F, Castañeda S, González-Juanatey C, Llorca J, Corrales A, Miranda-Filloy JA, Rueda-Gotor J, Gómez-Vaquero C, Rodríguez-Rodríguez L, Fernández-Gutiérrez B, Pascual-Salcedo D, Balsa A, López-Longo FJ, Carreira P, Blanco R, González-Álvaro I, Martín J, González-Gay MA. SMAD3 rs17228212 Gene Polymorphism Is Associated with Reduced Risk to Cerebrovascular Accidents and Subclinical Atherosclerosis in Anti-CCP Negative Spanish Rheumatoid Arthritis Patients. PLoS One. 2013 Oct 21;8(10):e77695

23. Geng H, Nandakumar KS, Xiong L, Jie R, Dong JH, Holmdahl R: Incomplete B cell tolerance in mice with circulating cartilage oligomeric matrix protein. Arthritis Rheum 65: 2301–2309, 2013.

24. Gerlag DM, Tak PP. How to perform and analyse synovial biopsies. Best Pract Res Clin Rheumatol. 2013 Apr;27(2):195-207. van Baarsen LG, de Hair MJ, Ramwadhdoebe TH, Zijlstra IJ, Maas M, Gerlag DM, Tak PP. The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis. Ann Rheum Dis. 2013 Aug;72(8):1420-4.

25. Goëb V, P Aegerter, R Parmar, P Fardellone, O Vittecoq, PG Conaghan, P Emery, X Le Loët, F Ponchel. Progression to rheumatoid arthritis in early inflammatory arthritis is associated with low IL-7 serum levels. Ann Rheum Dis 2013; 72:1032-1036

26. Günther C, Neumann H, Neurath MF, Becker C. Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut. 2013 Jul;62(7):1062-71. doi: 10.1136/gutjnl-2011-301364. Epub 2012 Jun 11.

27. Haag S, Schneider N, Mason DE, Tuncel J, Andersson IE, Peters EC,3 Burkhardt H,2,4 and Holmdahl R; Mass spectrometric analysis of citrullinated type II collagen reveals new citrulline-specific autoantibodies, which bind to human arthritic cartilage. Arthritis Rheum in press 2014

28. Hansson MG, van Ommen GJ, Chadwick R & Dillner J, Patients would benefit from simplified ethical review and consent procedure; Lancet Oncology online pre-publication March 21, 2013 http://dx.doi.org/10.1016/S1470-2045(13)70129-3

29. Hensvold AH, Magnusson PKE, Joshua V, Hansson M, Israelsson L, Jakobsson P-J, Holmdahl R, Malmström V, Askling J, Klareskog L and Catrina AI. Roles of environmental and genetic factors in the emergence of anti-citrullinated protein antibodies (ACPA) and ACPA-positive rheumatoid arthritis – an epidemiological investigation in twins. Ann Rheum Dis in press Epub Nov 25 2013

30. Herenius MM, Oliveira AS, Wijbrandts CA, Gerlag DM, Tak PP, Lebre MC. Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation. PLoS One. 2013;8(2):e57802.

31. Hoffmann MH, Bruns H, Bäckdahl L, Neregård P, Niederreiter B, Herrmann M, Catrina AI, Agerberth B, Holmdahl R. The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats. Ann Rheum Dis. 2013 Jul;72(7):1239-48.

32. Holmdahl R, Sareila O, Pizzolla A, Winter S, Hagert C, Jaakkola N, Kelkka T, Olsson LM, Wing K, Bäckdahl L. Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells. Antiox Redox Signal 2013; 18(12):1463-74

33. Holmdahl R. Studies of pre-RA synovial histology, a comparison with animal models. Arthritis Rheum (in press)

34. Holmqvist M, Raaschou P, Neovius M, Askling J. [Observational cohort studies. Overview and some examples from the field of drug safety]. Lakartidningen. 2013 Jan 16-22;110(3):82-4. Swedish. Eriksson JK, Neovius M, Ernestam S, Lindblad S, Simard JF, Askling J. Incidence of rheumatoid arthritis in Sweden: a nationwide population-based assessment of incidence, its determinants, and treatment penetration. Arthritis Care Res (Hoboken). 2013 Jun;65(6):870-8.

35. Hultqvist M, Olofsson P, Wallner F, Holmdahl R. Pharmacological potential of NOX2 agonists in inflammatory condition. Antioxid Redox Signal in press 2013

36. Ioannou M, Alissafi T, Boon L, Boumpas D, Verginis P. In vivo ablation of plasmacytoid dendritic cells inhibits autoimmunity through expansion of myeloid-derived suppressor cells. J Immunol. 2013;190(6):2631-40

37. Kelkka T, Angela Pizzolla A, Laurila JP, Friman T, Gustafsson R, Källberg E, Olsson O, Leanderson T, Rubin K, Salmi M, Jalkanen S, Holmdahl R. Mice lacking NCF1 exhibit reduced growth of implanted melanoma and carcinoma tumors. PLOSOne 2013; 8(12):e84148.

38. Kerkman PF, Rombouts Y, van der Voort EI, Trouw LA, Huizinga TW, Toes RE, Scherer HU. Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis. Ann Rheum Dis. 2013 Jul;72(7):1259-63. doi: 10.1136/annrheumdis-2012-202893. Epub 2013 Apr 26

39. Kessel C, Nandakumar KS, Peters FB, Gauba V, Schultz PG, Holmdahl R. A single functional group substitution in C5a breaks B and T cell tolerance and protects from experimental arthritis. Arthritis Rheum. 2013 Oct 21

40. Kokkonen H et al., Association of Antibodies Against Citrullinated Peptides with HLA Shared Epitope, PTPN22 1858T Variant, and Smoking in Individuals Prior to and After the Development of Rheumatoid Arthritis, 2013

41. Kyogoku C, Smiljanovic B, Grün JR, Biesen R, Häupl T, Hiepe F, Alexander T, Radbruch A, Grützkau A Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference?. Plos One. 2014

42. Liu BS, Stoop JN, Huizinga TW, Toes RE. IL-21 Enhances the Activity of the TLR-MyD88-STAT3 Pathway but Not the Classical TLR-MyD88-NF-κB Pathway in Human B Cells To Boost Antibody Production. J Immunol. 2013 Sep 16.

43. Maillette de Buy Wenniger LJ, Doorenspleet ME, Klarenbeek PL, Verheij J, Baas F, Elferink RP, Tak PP, de Vries N, Beuers U. Immunoglobulin G4+ clones identified by next-generation sequencing dominate the B cell receptor repertoire in immunoglobulin G4 associated cholangitis, Hepatology. 2013 Jun;57(6):2390-8. doi: 10.1002/hep.26232. Epub 2013 May

44. Marijnissen RJ, Roeleveld DM, Young D, Nickerson-Nutter C, Abdollahi-Roodsaz S, Garcia de Aquino S, van de Loo FA, van Spriel AB, Boots AM, van den Berg WB, Koenders MI. IL-21R-deficiency increases the initial TLR2 response but protects against joint pathology by reducing Th1/17 cells during SCW-arthritis. Arthritis Rheum. 2013 Dec 10. doi: 10.1002/art.38312

45. McAllister K, Yarwood A, Bowes J, Orozco G, Viatte S, Diogo D, Hocking LJ, Steer S, Wordsworth P, Wilson AG, Morgan AW; UK Rheumatoid Arthritis Genetics Consortium; Rheumatoid Arthritis Consortium International, Kremer J, Pappas D, Gregersen P, Klareskog L, Plenge R, Barton A, Greenberg J, Worthington J, Eyre S. Meta-analysis identifies BACH2 and RAD51B as rheumatoid arthritis susceptibility loci. Arthritis and Rheumatism 2013 Sep 10. doi: 10.1002/art.38183

46. Muller PC, Anink J, Shi J, Levarht EW, Reinards TH, Otten MH, van Tol MJ, Jol-van der Zijde CM, Brinkman DM, Allaart CF, Hoppenreijs EP, Koopman-Keemink Y, Kamphuis SS, Dolman K, van den Berg JM, van Rossum MA, van Suijlekom-Smit LW, Schilham MW, Huizinga TW, Toes RE, Ten Cate R, Trouw LA. Anticarbamylated protein (anti-CarP) antibodies are present in sera of juvenile idiopathic arthritis (JIA) patients. Ann Rheum Dis. 2013 Dec 1;72(12):2053-5. doi: 10.1136/annrheumdis-2013-203650. Epub 2013 Jul 19.

47. Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Louis Bridges Jr S, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M; the RACI consortium; the GARNET consortium, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2013 Dec 25. doi: 10.1038/nature12873. [Epub ahead of print]

48. Pieper J, Johansson S, Snir O, Linton L, Rieck M, Buckner JH, Winqvist O, van Vollenhoven R and Malmström V. Peripheral and site-specific CD4+CD28null T cells from Rheumatoid Arthritis patients show distinct characteristics and function. Scand J Immunol in press EPub Dec 9, 2013

49. Pieper J, Herrath J, Raghavan S, Muhammad K, Vollenhoven Rv, Malmström V. CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients. BMC Immunol. 2013 Aug 5;14:34.

50. Pizzolla A, Wing K, Holmdahl R: A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice. Arthritis without reactive oxidative species and complement. 2013. Am J Pathol 183(4):1144-55

51. Plenge Robert, Yukinori Okada, Di Wu, Gosia Trynka, Towfique Raj, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Shinji Yoshida, Robert Graham, Arun Manoharan, Ward Ortmann, Tushar Bhangale, Joshua Denny, Robert Carroll, Anne Eyler, Jeffrey Greenberg, Joel Kremer, Dimitrios Pappas, Lei Jiang, Jian Yin, Lingying Ye, Ding-Feng Su, Jian Yang, Gang Xie, Ed Keystone, Harm-Jan Westra, Tõnu Esko, Xuezhong Zhou, Namrata Gupta, Daniel Mirel, Eli Stahl, Dorothee Diogo, Jing Cui, Katherine Liao, Michael Guo, Keiko Myouzen, Takahisa Kawaguchi, Marieke Coenen, Piet van Riel, Mart van de Laar, Henk-Jan Guchelaar, Tom Huizinga, Philippe Dieudé, Xavier Mariette, S. Louis Bridges Jr., Alexandra Zhernakova, Rene Toes, Paul-Peter Tak, Corinne Miceli-Richard, So-Young Bang, Hye-Soon Lee, Hyon Choi, Yoichiro Kamatani, Pilar Galan, Mark Lathrop, RACI consortium, GARNET consortium, Steve Eyre, John Bowes, Anne Barton, Niek de Vries, Larry Moreland, Lindsey Criswell, Elizabeth Karlson, Atsuo Taniguchi, Ryo Yamada, Michiaki Kubo, Jun Liu, Jane Worthington, Sang-Cheol Bae, Leonid Padyukov, Lars Klareskog, Peter Gregersen, Soumya Raychaudhuri, Barbara Stranger, Philip De Jager, Lude Franke, Peter Visscher, Matthew Brown, Hisashi Yamanaka, Tsuneyo Mimori, Atsushi Takahashi, Huji Xu, Tim Behrens, Katherine Siminovitch, Shigeki Momohara, Fumihiko Matsuda, Kazuhiko Yamamoto, Andres Metspalu, Javier Martin, Miguel Gonzalez-Gay, Luis Rodriguez-Rodriguez, Solbritt Rantapää-Dahlqvist, and Lisbeth Lisbeth. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2013 accepted. Paper #2013-06-07820D

52. Ponchel F, V Goëb, R Parmar, Y El-Sherbiny, M Boissinot, J El Jawhari, A Burska, EM Vital, S Harrison, PG Conaghan, E Hensor, P Emery. An immunological biomarker to predict MTX response in early RA., Ann Rheum Dis 2013

53. Quirke AM, Lugli EB, Wegner N, Hamilton BC, Charles P, Chowdhury M, Ytterberg AJ, Zubarev RA, Potempa J, Culshaw S, Guo Y, Fisher BA, Thiele G, Mikuls TR, Venables PJ Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis. Ann Rheum Dis. 2013 Mar 28. [Epub ahead of print]

54. Raposo B, Dobritzsch D, Ge C, Ekman D, Xu B, Lindh I, Förster M, Uysal H, Nandakumar KS, Schneider G, Holmdahl R; Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms. J Exp Med in press 2014

55. Revu S, Neregård P, Af Klint E, Korotkova M, Catrina AI. Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate. Arthritis Res Ther. 2013 Dec 3;15(6):R205.

56. Reynisdottir G, Karimi R, Joshua V, Olsen H, Hensvold AH, Harju A, Engström M, Grunewald J, Nyren S, Eklund A, Klareskog L, Sköld CM, Catrina AI. Structural lung changes and local anti-citrulline immunity are early features of anti citrullinated-proteins antibodies positive rheumatoid arthritis. Arthritis Rheum. 2013 Oct 21.

57. Rodrigues-Sousa T, Carvalheiro H, Ladeirinha AF, Raposo B, Alarcão A, Cabrita A, Holmdahl R, Carvalho L, Paulo Rodrigues-Santos P, Souto-Carneiro MM. Deficient production of reactive oxygen species leads to a chronic DSS-induced colitis in Ncf1-mutant B10.Q mice. PLOSOne (in press)

58. Rose T, Grützkau A, Hirseland H, Huscher D, Dähnrich C, Dzionek A, Ozimkowski T, Schlumberger W, Enghard P, Radbruch A, Riemekasten G, Burmester GR, Hiepe F, Biesen R. IFNα and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus Ann Rheum Dis. 2013 Oct;72(10):1639-45

59. Ruiz-Heiland G, Zhao Y, Derer A, Braun T, Engelke K, Neumann E, Mueller-Ladner U, Liu Y, Zwerina J, Schett G. Deletion of the receptor tyrosine kinase Tyro3 inhibits synovial hyperplasia and bone damage in arthritis. Ann Rheum Dis. 2013; in press

60. Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G. PPARβ/δ governs Wnt signaling and bone turnover. Nat Med. 2013 ;19(5):608-13.

61. Shakya AK, Holmdahl R, Nandakumar KS, Kumar A. Polymeric cryogels are biocompatible and their biodegradation is independent of oxidative radicals. J Biomed Mater Res A. 2013 Oct 19

62. Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, Toes RE, Trouw LA. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2013 Oct 28. pii: S1568-9972(13)00201-2. doi: 10.1016/j.autrev.2013.10.008. [Epub ahead of print]

63. Shi J, van de Stadt LA, Levarht EW, Huizinga TW, Toes RE, Trouw LA, van Schaardenburg D. anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis. Arthritis Rheum. 2013 Apr;65(4):911-5. doi: 10.1002/art.37830

64. Shi J, van de Stadt LA, Levarht EW, Huizinga TW, Hamann D, van Schaardenburg D, Toes RE, Trouw LA. Anti-carbamylated protein (anti-CarP) antibodies precede the onset of rheumatoid arthritis. Ann Rheum Dis. 2013 Dec 13

65. Snir O, Hesselberg E, Amoudruz P, Klareskog L, Zarea-Ganji I, Catrina AI, Padyukov L, Malmström V, Seddighzadeh M. Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis. Genes Immun. 2013 Mar;14(2):83-9. doi: 10.1038/gene.2012.56.

66. Stjernschantz Forsberg J, Hansson MG, Eriksson S. Why participating in )certain) scientific research is a moral duty, J Med Ethics, online pre-publication, doi:10.1136/medethics-2012-100859

67. Stock M, Böhm C, Scholtysek C, Englbrecht M, Fürnrohr BG, Klinger P, Gelse K, Gayetskyy S, Engelke K, Billmeier U, Wirtz S, van den Berg W, Schett G. Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis. Arthritis Rheum. 2013 ;65(9):2310-22

68. Strollo R, F Ponchel, V Malmstro, P Rizzo, M Bombardieri, CY. Wenham, R Landy, D Perret, F Watt, V M. Corrigall, PG. Winyard, P Pozzilli, P G. Conaghan, GS. Panayi, L Klareskog, P Emery & A Nissim. Autoantibodies to Posttranslationally Modified Type II Collagen as Potential Biomarkers for Rheumatoid Arthritis. Arthritis & Rheumatism 2013; 65(7); 1702–1712

69. Suurmond J, Stoop JN, Rivellese F, Bakker AM, Huizinga TW, Toes RE. Activation of human basophils by combined Toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells. Eur J Immunol. 2013 Oct 9. doi: 10.1002/eji.201343617. [Epub ahead of print]

70. Suurmond J, van Heemst J, van Heiningen J, Dorjée AL, Schilham MW, van der Beek FB, Huizinga TW, Schuerwegh AJ, Toes RE. Communication between human mast cells and CD4+ T cells through antigen-dependent interactions. Eur J Immunol. 2013 Apr 18. doi: 10.1002/eji.201243058. [Epub ahead of print]

71. Suwannalai P, Britsemmer K, Knevel R, Scherer HU, Levarht EW, van der Helm-van Mil AH, van Schaardenburg D, Huizinga TW, Toes RE, Trouw LA. Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis. Ann Rheum Dis. 2013 Mar 5. [Epub ahead of print]

72. Teruel M, McKinney C, Balsa A, Pascual-Salcedo D, Rodriguez-Rodriguez L, Ortiz AM, Gómez-Vaquero C, González-Gay MA, Smith M, Witte T, Merriman T, Lie BA, Martin J Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis.. PLoS One. 2013 Jul 5;8(7):e68295

73. Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC. The TNFα-induced miR-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheum 2013; 65:916-27

74. Trouw LA, Daha N, Kurreeman FA, Böhringer S, Goulielmos GN, Westra HJ, Zhernakova A, Franke L, Stahl EA, Levarht EW, Stoeken-Rijsbergen G, Verduijn W, Roos A, Li Y, Houwing-Duistermaat JJ, Huizinga TW, Toes RE.Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. Clin Exp Immunol. 2013 Jul;173(1):76-83

75. Tuncel J, Haag S, Yau ACY, Norin U, Baud A, Lönnblom E, Maratou K, Ytterberg J, Ekman D, Thordardottir S, Johannesson M, Gillett A, Stridh P, Jagodic M, Olsson T, Fernández-Teruel A, Zubarev RA, Mott R, Aitman TJ, Flint J and Holmdahl R; Natural Polymorphisms in Tap2 Influence Negative Selection and CD4:CD8 Lineage Commitment in the Rat. PLOS Gen in press 2014

76. Umicevic Mirkov M, Cui J, Vermeulen SH, Stahl EA, Toonen EJ, Makkinje RR, Lee AT, Huizinga TW, Allaart R, Barton A, Mariette X, Miceli CR, Criswell LA, Tak PP, de Vries N, Saevarsdottir S, Padyukov L, Bridges SL, van Schaardenburg DJ, Jansen TL, Dutmer EA, van de Laar MA, Barrera P, Radstake TR, van Riel PL, Scheffer H, Franke B, Brunner HG, Plenge RM, Gregersen PK, Guchelaar HJ, Coenen MJ. Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis. Ann Rheum Dis. 2013 Aug;72(8):1375-81.

77. van Baarsen LG, de Hair MJ, Ramwadhdoebe TH, Zijlstra IA, Maas M, Gerlag DM, Tak PP. The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis. Ann Rheum Dis. 2013 May 9. [Epub ahead of print]

78. van den Brand BT, Abdollahi-Roodsaz S, Vermeij EA, Bennink MB, Arntz OJ, Rothlin CV, van den Berg WB, van de Loo FA. Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis. Arthritis Rheum. 2013; 65(3):671-80

79. van den Brand BT, Abdollahi-Roodsaz S, Bennink MB, Bussink J, Arntz OJ, van den Berg WB, van de Loo FA. Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis. Ann Rheum Dis. 2013; 72(8):1407-15

80. van de Sande MG, de Launay D, de Hair MJ, García S, van de Sande GP, Wijbrandts CA, Gerlag DM, Reedquist KA, Tak PP. Local synovial engagement of angiogenic TIE-2 is associated with the development of persistent erosive rheumatoid arthritis in patients with early arthritis. Arthritis Rheum. 2013 Dec;65(12):3073-83.

81. Viberg J, Hansson MG, Langenskiöld S, Segerdahl P,Incidental findings: the time is not yet ripe for a policy for biobanks; European Journal of Human Genetics advance online publication, 25 September 2013; doi:10.1038/ejhg.2013.217

82. Walter GJ, Evans HG, Menon B, Gullick NJ, Kirkham BW, Cope AP, Geissmann F, Taams LS. Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45ro+CD25+CD127(low) regulatory T cells. Arthritis Rheum. 2013 Mar;65(3):627-38.

83. Willemze A, Shi J, Mulder M, Stoeken-Rijsbergen G, Drijfhout JW, Huizinga TW, Trouw LA, Toes RE. The concentration of anticitrullinated protein antibodies in serum and synovial fluid in relation to total immunoglobulin concentrations. Ann Rheum Dis. 2013 Mar 13.

84. Wittkopf N., C. Günther, E. Martini, G. He, K. Amann, Y.-W. He, M. Schuchmann, M.F. Neurath. C. Becker. Cellular FLICE-Like Inhibitory Protein Secures Intestinal Epithelial Cell Survival and Immune Homeostasis by Regulating Caspase-8. Gastroenterology. 2013. 145(6):1369-79.

85. Wittkopf N., M.F. Neurath, C. Becker. Immune-epithelial crosstalk at the intestinal surface. J Gastroenterol. 2014. In press.

86. Yamamoto H, Fara A, Dasgupta P and Kemper, C. CD46: The multitasker of complement proteins. Intern J Biochem Cell Biol 2013;45:2808-2820.

87. Yarwood A, Sebastien Viatte, Darren Plant, Ann W Morgan, John Isaacs, Anthony G Wilson, Kimme Hyrich, Steve Eyre, Anne Barton, Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS). Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach. Annals of the Rheumatic Diseases 2013 Dec 9. Doi:10.1136/annrheumdis-2013-204443

88. Yarwood A, Han B, Raychaudhuri S, Bowes J, Lunt M, Pappas DA, Kremer J, Greenberg JD, Plenge R, Rheumatoid Arthritis Consortium International (RACI), Worthington J, Barton A, Eyre S. A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk. Annals of the Rheumatic Diseases 2013 Oct 3. Doi: 10.1136/annrheumdis-2013-204133

89. Yarwood A, Paul Martin, John Bowes, Mark Lunt, Jane Worthington, Anne Barton, Steve Eyre. Enrichment of Vitamin D response elements in RA associated loci supports a role for vitamin D in the pathogenesis of RA. Genes and Immunity 2013 doi: 10.1038/gene.2013.23

90. Zervou MI, Myrthianou E, Flouri I, Plant D, Chlouverakis G, Castro-Giner F, Rapsomaniki P, Barton A, Boumpas DT, Sidiropoulos P, Goulielmos GN. Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population. PLoS One. 2013;8(9):e74375

 

2012

Abdollahi-Roodsaz S, van de Loo FA, Koenders MI, Helsen MM, Walgreen B, van den Bersselaar LA, Arntz OJ, Takahashi N, Joosten LA, van den Berg WB. Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice. Arthritis Rheum. 2012 Jun;64(6)

Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, Horn A, Kireva T, Beyer C, Zwerina J, Schneider H, Sadowski A, Riener MO, MacDougald OA, Distler O, Schett G, Distler JH. Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis. Nat Commun. 2012 Mar 13;3:735.

Amara K, Steen J, Murray F, Hombach H, Fernandez-Rodriguez BM, Joshua V, Engström M, Snir O, Israelsson L, Catrina AI, Wardemann H, Corti D, Meffre E, Klareskog L and Malmström V. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias towards citrullinated autoantigen recognition. J Exp Med 2013 electronic publication February 25, 2013

Ammari M, C. Jorgensen and F. Apparailly. 2013. Impact of microRNAs on the understanding and treatment of rheumatic diseases. Current Opinion Rheum (in press)

Apparailly F and Jorgensen C. 2013. Innovative siRNA-based therapeutic approaches for rheumatic diseases. Perspectives for Nature Reviews Rheumatology 9(1): 56-62 (IF=8,38)

Becker C., A.J. Watson, M.F.Neurath. Complex Roles of Caspases in the Pathogenesis of Inflammatory Bowel Disease. Gastroenterology. 2012. Accepted

Biliavska I, Stamm TA, Martinez-Avila J, Huizinga TW, Landewé RB, Steiner G, Aletaha D, Smolen JS, Machold KP. Application of the 2010 ACR/EULAR classification criteria in patients with very early inflammatory arthritis: analysis of sensitivity, specificity and predictive values in the SAVE study cohort. Ann Rheum Dis 2012 Sep 15 (in press).

Bonelli M, Ferner E, Göschl L, Blüml S, Hladik A, Karonitsch T, Kiener H, Byrne R, Niederreiter B, Steiner C, Rath E, Bergmann M, Smolen J, Scheinecker C. Abatacept (CTLA-4Ig) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis. Arthritis Rheum 2012 Nov 30. doi: 10.1002/art.37787. [Epub ahead of print].

Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, Stenlund H, Rönnelid J, Klareskog L, Dahlqvist SR., Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum. 2013 Jan 10. doi: 10.1002/art.37835. [Epub ahead of print]

Byrne R, Rath E, Hladik A, Niederreiter B, Bonelli M, Frantal S, Smolen JS, Scheinecker C. A dynamic real tim in vivo and static ex vivo analysis of granulomonocytic cell migration in the collagen-induced arthritis model Plos one 2012, 7(4):e35194.

Bäcklund J, Li C, Jansson E, Carlsen S, Merky P, Nandakumar KS, et al. C57BL/6 mice need MHC class II Aq to develop collagen-induced arthritis dependent on autoreactive T cells. Ann. Rheum. Dis. 2012 Oct 5.

Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A, Arena V, Biroulet LP, Caprioli F, Passini N, Panina-Bordignon P, Repici A, Malesci A, Rutella S, Rescigno M, Danese S. The Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response. Gastroenterology. 2012 Oct 26. doi:pii: S0016-5085(12)01598-3.  10.1053/j.gastro. 2012.10.040.

Churchman, S. J. Geiler, R. Parmar, E. Horner, L. Church, P. Emery, M. Buch, M. McDermott, F. Ponchel. Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor. Clin Exp Rheum 2011-1129151151-5235

de Hair MJ, Landewé RB, van de Sande MG, van Schaardenburg D, van Baarsen LG, Gerlag DM, Tak PP. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis. 2012 Nov 17

de Hair MJ, Zijlstra IA, Boumans MJ, van de Sande MG, Maas M, Gerlag DM, Tak PP. Hunting for the pathogenesis of rheumatoid arthritis: core-needle biopsy of inguinal lymph nodes as a new research tool. Ann Rheum Dis. 2012 Nov;71(11):1911-2.

Evers K, Forsberg J, Hansson MG. Commercialization of biobanks. Biopreservation and Biobanking Vol 10,(1), DOI: 10.1089/bio.2011.0041

Förster M, Raposo B, Ekman D, Klaczkowska D, Popovic M, Nandakumar KS, et al. Genetic control of antibody production during collagen induced arthritis development in heterogeneous stock mice. Arthritis Rheum. 2012 Nov;64(11):3594–603..

García-Bermúdez M, López-Mejías R, González-Juanatey C, Corrales A, Robledo G, Castañeda S, Miranda-Filloy JA, Blanco R, Fernández-Gutiérrez B, Balsa A, González-Alvaro I, Gómez-Vaquero C, Llorca J, Martín J, González-Gay MA Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis..PLoS One. 2012;7(10):e47166.

Geng H, Nandakumar KS, Pramhed A, Aspberg A, Mattsson R, Holmdahl R. Cartilage oligomeric matrix protein specific antibodies are pathogenic. Arthritis Res Ther. 2012 Aug 20;14(4):R191.

Gerlag DM, Raza K, van Baarsen LG, Brouwer E, Buckley CD, Burmester GR, Gabay C, Catrina AI, Cope AP, Cornelis F, Dahlqvist SR, Emery P, Eyre S, Finckh A, Gay S, Hazes JM, van der Helm-van Mil A, Huizinga TW, Klareskog L, Kvien TK, Lewis C, Machold KP, Rönnelid J, van Schaardenburg D, Schett G, Smolen JS, Thomas S, Worthington J, Tak PP. EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann Rheum Dis. 2012 May;71(5):638-41.

Gina J. Walter, Hayley G. Evans, Bina Menon, Nicola J. Gullick, Bruce W. Kirkham, Andrew P. Cope, Frédéric Geissmann, and Leonie S. Taams. Interaction with activated monocytes enhances cytokine expression and suppressive activity of human CD4+CD45RO+CD25+CD127low regulatory T cells. Arthritis Rheum. 2012 Dec 21 (in press)

Goëb V, Aegerter P, Parmar, R, Fardellone P, Vittecoq O, Conaghan PG, Emery P, Le Loët X, Ponchel F. Progression to rheumatoid arthritis in early inflammatory arthritis is associated with low IL-7 serum levels. ARD, in press.

Günther C, Neumann H, Neurath MF, Becker C. Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium. Gut. 2012 Jun 27. [Epub ahead of print] PubMed PMID: 22689519.

Haag S, Uysal H, Bäcklund J, Tuncel J, Holmdahl R. Human α-enolase is immunogenic, but not arthritogenic, in HLA-DR4 transgenic mice. Comment on the article by Kinloch et al. Arthritis Rheum. 2012 May;64(5):1689-91

Hansson M, Mathsson L, Schlederer T, Israelsson L, Matsson P, Nogueira L, Jakobsson PJ, Lundberg K, Malmström V, Serre G, Holmdahl R, Nystrand M, Klareskog L, Rönnelid J. Validation of a multiplex chip-based assay for the detection of autoantibodies against citrullinated peptides. Arthritis Res Ther. 2012 Oct 1;14(5):R201.

Hansson M, Where should we draw the line between quality of care and other ethical concerns related to medical registries and biobanks? Theoretical Medicine and Bioethics, 2012; 33(4):313-323.

Hansson MG, Validate DNA-findings before telling donors, Letter, Nature 2012;484(7395):455

Hansson MG, Simonsson B, Feltelius N, Forsberg JS, Hasford J. Medical registries represent vital patient interests and should not be dismantled by stricter regulation. Cancer Epidemiol. 2012 Jul 13. [Epub ahead of print] 

Hansson MG, Gattorno M, Forsberg JS, Feltelius N, Martini A, Ruperto N. Ethics bureaucracy: a significant hurdle for collaborative follow-up of drug effectiveness in rare childhood diseases. Arch Dis Child. 2012 Jun;97(6):561-3.

Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, Baum, W, Nimmerjahn F, Szarka E, Sarmay G, Krumbholz G, Neumann E, Toes R, Scherer HU, Catrina AI, Klareskog L, Jurdic P, Schett G. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest. 2012 Apr 16.

Heiland GR, Appel H, Poddubnyy D, Zwerina J, Hueber A, Haibel H, Baraliakos X, Listing J, Rudwaleit M, Schett G, Sieper J. High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis. Ann Rheum Dis. 2012 Apr;71(4):572-4.

Herman S, Kny A, Schorn C, Pfatschbacher J, Niederreiter B, Herrmann M, et al. Cell death and cytokine production induced by autoimmunogenic hydrocarbon oils. Autoimmunity. 2012 Dec;45(8):602-11

Hoffmann MH, Bruns H, Bäckdahl L, Neregård P, Niederreiter B, Herrmann M, et al. The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats. Ann. Rheum. Dis. 2012 Nov 29.   

Holmdahl R, Sareila O, Pizzolla A, Winter S, Hagert C, Jaakkola N, et al. Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells. Antioxid Redox Signal. 2012 Aug 17

Johnsson L, Helgesson G, Hansson MG, Eriksson S. Adequate trust avails mistaken trust matters on the moral responsibility of doctors as proxies for patients’ trust in biobank research. Bioethics. 2012 Jun 10. doi: 10.1111/j.1467-8519.2012.01977

Klarenbeek PL, M J H de Hair, M E Doorenspleet, B D C van Schaik, R E E Esveldt, M G H van de Sande, T Cantaert, D M Gerlag, D Baeten,1 A.H.C van Kampen, F Baas, P P Tak, N de Vries. Inflamed target tissue provides a specific niche for highly expanded T-cell clones in early human autoimmune disease. Ann Rheum Dis. 2012 Jun;71(6):1088-93

Klein K, Ospelt C, Gay S. Epigenetic contributions in the development of rheumatoid arthritis. Arthritis Res Ther. 2012 Nov 9;14(6):227.

Koenders MI, Marijnissen RJ, Joosten LA, Abdollahi-Roodsaz S, Di Padova FE, van de Loo FA, Dulos J, van den Berg WB, Boots AM. T cell lessons from the rheumatoid arthritis synovium SCID mouse model: CD3-rich synovium lacks response to CTLA-4Ig but is successfully treated by interleukin-17 neutralization. Arthritis Rheum. 2012 Jun;64(6):1762-70. doi: 10.1002/art.34352.

Kyogoku C, Grün J, Biesen R, Alexander T, Häupl T, Hiepe F, Radbruch A and Grützkau A.  Cell-specific type I IFN signatures in autoimmunity and viral infection: what makes the difference? ( under review).   

Le Friec G, Sheppard D, Whiteman P, Karsten CM, Shamoun SA, Laing A, Bugeon L, Dallman MJ, Melchionna T, Chillakuri C, Smith RA, Drouet C, Couzi L, Fremeaux-Bacchi V, Köhl J, Waddington SN, McDonnell JM, Baker A, Handford PA, Lea SM, Kemper C. The CD46-Jagged1 interaction is critical for human T(H)1 immunity. Nat Immunol. 2012 Dec;13(12):1213-21.

Lundberg K, Bengtsson C, Kharlamova N, Reed E, Jiang X, Kallberg H, Pollak-Dorocic I, Israelsson L, Kessel C, Padyukov L, Holmdahl R, Alfredsson L, Klareskog L. Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. Ann Rheum Dis. 2012 Sep 8. [Epub ahead of print]

Niederer F, Trenkmann M, Ospelt C, Karouzakis E, Neidhart M, Stanczyk J, Kolling C, Gay RE, Detmar M, Gay S, Jüngel A, Kyburz D. Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum. 2012 Jun;64(6):1771-9.

Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M, Mills GB, Gay S, Kollias G, Aidinis V. Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. J Exp Med. 2012 May 7;209(5):925-33.

Olsson LM, Holmdahl R. Copy number variation in autoimmunity – importance hidden in complexity?Eur. J. Immunol. 2012 Aug;42(8):1969–76.

Pandis I, Ospelt C, Karagianni N, Denis MC, Reczko M, Camps C, Hatzigeorgiou AG, Ragoussis J, Gay S, Kollias G. Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model.Ann Rheum Dis. 2012 Oct;71(10):1716-23.

Pizzolla A, Hultqvist M, Nilson B, Grimm MJ, Eneljung T, Jonsson I-M, et al. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol. 2012 May 15;188(10):5003–11

Ponchel F, V Goëb, R Parmar, Y El-Sherbiny, M Boissinot, J El Jawhari, A Burska, E Vital, S Harrison, Elisabeth Hensor,PG Conaghan, Pl Emery. An immunological window of opportunity defines the ability of early RA patient to achieve remission with first anti-rheumatic treatment. Arthritis & Rheum, 2012. Under minor revision

Ponchel F, E Vital, SR Kingsbury YM. El-Sherbiny. CD4+ T-cell subsets in Rheumatoid Arthritis. Int J Clinical Rheumatology, 2012: 7. 37-53.

Raza K, Saber TP, Kvien TK, Tak PP, Gerlag DM. Timing the therapeutic window of opportunity in early rheumatoid arthritis: proposal for definitions of disease duration in clinical trials. Ann Rheum Dis. 2012 Aug 31. [Epub ahead of print] PubMed PMID: 22941769.

Rose T, Grützkau A, Hirseland H, Huscher D, Dähnrich C, Dzionek A, Ozimkowski T, Schlumberger W, Enghard P, Radbruch A, Riemekasten G, Burmester GR, Hiepe F,  and Biesen R. IFNa and its response proteins, IP-10 and SIGLEC-1, are biomarkers of disease activity in systemic lupus erythematosus. Ann Rheum Dis. 2012 Oct 31.

Schett G, Gravallese E.Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012 Nov;8(11):656-64

Shi J, van de Stadt LA, Levarht EW, Huizinga TW, Toes RE, Trouw LA, van Schaardenburg D.Anti Carbamylated Protein Antibodies (anti-CarP) are present in arthralgia patients and predict the development of rheumatoid arthritis, Arthritis Rheum, 2012 Dec 21. Epub ahead of print.

Shi J, Willemze A, Janssen GM, van Veelen PA, Drijfhout JW, Cerami A, Huizinga TW, Trouw LA, Toes RE. Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the ‘AMC-Senshu’ method. Ann Rheum Dis. 2012 Jul 26. [Epub ahead of print] PubMed PMID: 22843489 

Smiljanovic B, Grün JR, Biesen R, Schulte-Wrede U, Baumgrass R, Stuhlmüller B, Maslinski W, Hiepe F, Burmester GR, Radbruch A, Häupl T, Grützkau A. The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: how monocytes manage the impact of cytokines. J Mol Med (Berl). 2012 Nov;90(11):1295-309.

Snir O, Hesselberg E, Amoudruz P, Klareskog L, Zarea-Ganji I, Catrina AI, Padyukov L, Malmström V and Seddigzadeh M. Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis. Genes Immunity 2012 Epub ahead of print PMID 23254357

Snir O, Bäcklund J, Boström J, Andersson I, Kihlberg J, Buckner JH, Klareskog L, Holmdahl R, Malmström V. Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis. Arthritis Rheum. 2012 Aug;64(8):2482-8.

Stjernschantz-Forsberg J, Hansson MG, Eriksson S, Biobank research: who benefits from individual consent?, British Medical Journal2011; 343:d5647.

Strollo R, F Ponchel, V Malmström, P Rizzo, M Bombardieri, C Wenham, R Landy, D Perret, VM Corrigall, PG Winyard, P Pozzilli, PG Conaghan, GS Panayi, L Klareskog,P Emery& A Nissim. , Auto-antibodies to post translationally modified type II collagen as potential biomarkers for rheumatoid arthritis. Arthritis Rheum, 2012. Under minor revision

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van den Brand BT, Abdollahi-Roodsaz S, Vermeij EA, Bennink MB, Arntz OJ, Rothlin CV, van den Berg WB, van de Loo FA Therapeutic efficacy of Tyro3, Axl, and MerTK agonists in collagen-induced arthritis.. Arthritis Rheum. 2012 Nov 30. doi: 10.1002/art.37786.

van den Brand BT, Abdollahi-Roodsaz S, Bennink MB, Bussink J, Arntz OJ, van den Berg WB, van de Loo FA. Toll-like receptor 4 in bone marrow-derived cells as well as tissue-resident cells participate in aggravating autoimmune destructive arthritis. Ann Rheum Dis. 2013 Jan

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Willemze A, Böhringer S, Knevel R, Levarht EW, Stoeken-Rijsbergen G, Houwing-Duistermaat JJ, van der Helm-van Mil AH, Huizinga TW, Toes RE, Trouw LA. The ACPA recognition profile and subgrouping of ACPA-positive RA patients. Ann Rheum Dis. 2012 Feb;71(2):268-74. Epub 2011 Oct 13.

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2011

Cope A, Le Friec G, Cardone J, Kemper C. The Th1 life cycle: molecular control of IFN-γ to IL-10 switching. Trends Immunol. 2011 Jun;32(6):278-86. Epub 2011 Apr 30. Review.

Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA,
Levarht NE, van der Helm-van Mil AH, Cerami A, Huizinga TW, Toes RE, Trouw LA.
Autoantibodies recognizing carbamylated proteins are present in sera of patients
with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci U S A.
2011 Oct 18;108(42):17372-7

Suwannalai P, Willemze A, van Toorn L, Stoeken-Rijsbergen G, Levarht N, Drijfhout JW, Huizinga TW, Toes RE, Trouw LA The fine specificity of IgM anti-citrullinated protein antibodies (ACPA) is different from that of IgG ACPA. Arthritis Res Ther.  2011;13(6):R195. Epub 2011 Nov 30.

Vazgiourakis VM, Zervou MI, Choulaki C, Bertsias G, Melissourgaki M, Yilmaz N,Sidiropoulos P, Plant D, Trouw LA, Toes RE, Kardassis D, Yavuz S, Boumpas DT,Goulielmos GN. A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. Ann Rheum Dis. 2011 Sep 12.

Willemze A, Böhringer S, Knevel R, Levarht EN, Stoeken-Rijsbergen G,
Houwing-Duistermaat JJ, van der Helm-van Mil AH, Huizinga TW, Toes RE, Trouw LA.
The ACPA recognition profile and subgrouping of ACPA-positive RA patients. Ann
Rheum Dis. 2011 Oct 13
. [Epub ahead of print]