University of Oxford, UK

Principal Investigator:
Patrick J Venables

Main tasks in the project and previous experience relevant to those tasks:

Task 1. Development of the animal model of citrullinated enolase-induced arthritis in DR4 transgenic mice (WP1). Citrullinated enolase was discovered as a major autoantigen in rheumatoid arthritis by my team at the KennedyOxford University Institute. In collaboration with the Karolinska we have shown distinct gene environment associations, between specific antibodies to citrullinated enolase, DR4 alleles and smoking. Recently we have discovered a new model of RA in DR4 transgenic mice which parallels this specific gene autoantibody interaction in human disease.

Task 2. We will also contribute to the cohorts of RA and pre-RA serum samples for WP5.

Short profile of the staff who will carry out the work:

Prof Patrick Venables: Head of the autoimmunity group.
Dr Richard Williams: Head of the of the animal models group
Dr Andrew Kinloch: Post doctoral Research fellow.
New appointment of Post postdoctoral research assistant funded by IMI