Biomedical Sciences Research Center “Alexander Fleming” (Fleming)

Principal Investigator:
Dr. George Kollias

Main tasks in the project and previous experience relevant to those tasks:

Main tasks: (1) generation, archiving and validation of data on treatment responses in animal models, (2) molecular profiling and genome-wide analysis of arthritic joints, (3) generation of new transgenic animal models for arthritis (4) establishment of TheRAbase, an RA-specific database for animal model storage and analysis, (5) integration, comparison and modeling of treatment responses in animal models and alignment to human disease, (6) identification and validation of novel targets, pathways and translational biomarkers, (7) develop novel therapeutic modalities for RA, (8) serve as a link to the BTDC project (IMI5)

Previous expertise: Animal models of Arthritis, transgenesis and gene targeting; molecular and Cellular pathways; genomic profiling; cellular assays; preclinical drug evaluation; miRNA bioinformatics; computational expression profiling; functional predictions; mouse biobanking; relational databases; chemoinformatics.

Short profile of the staff who will carry out the work:

WP1/WP4

MSc. Yiannis Pandis

Dr. Christophoros Nikolaou

Dr. Christina Chandras

MSc. Michalis Zouberakis

WP3

Dr. Vaggelis Ntougkos

WP8

Dr. Vasiliki Koliaraki

Management

Dr. Piyi Papadaki

Dr. Alexandra Boutla

The PI’s group has close, internal collaborations with the groups of Dr. Iannis Talianidis (Director of the Institute of Molecular Biology and Genetics), expert in the field of transcriptional and epigenetic gene regulation, and Dr. Artemis Hatzigeorgiou (Researcher C’, Institute of Molecular Oncology), expert in the field of miRNA bioinformatics and gene network analysis).